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The first Major League game played by the Boston Americans (Red Sox) was on April 26, 1901. The Americans lost to the Baltimore Oriloes 1-0. The Baltimore Orioles team would later become the New York Yankees.
The first time the two teams played each other was on April 26, 1901. The Baltimore Orioles defeated the Boston Americans by the score of 10-6. In 1901 those were the original names of the Yankees and Red Sox.