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ANSWER Centre College's 1921 upset of Harvard is currently ranked No. 2 in an ESPN Online poll of "greatest College Football upsets." At last tally, the "Praying Colonels" victory over a Crimson team that was undefeated in five years pulled in 28.3 percent of votes, second only to Kansas State's 2003 upset of Oklahoma.

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Giants over the Patriots

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Q: What was the biggest upset in the history of college football?
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