Ipswich 6-0 Manchester United. 1st March 1980. Also, Ipswich missed 3 penalties (one was retaken) Hope this helps
Man Utd first lost by 7 goals away to Blackburn Rovers on 10 April 1926 (0-7).
They have since lost by this margin to Aston Villa and Wolves.
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Manchester United's biggest win: 26 September 1956 - Manchester United 10-0 RSC Anderlecht Scorers: Tommy Taylor 8, 20, 54. Dennis Violett 26, 39, 40, 75. William Whelan 63, 89. John Berry 78.