Former Detroit Lion Greg Landry's longest run from scrimmage was 76 yards. Landry's career best run occurred 9/20/1970 in the first game of the 1970 season versus the Green Bay Packers. It was his only rushing attempt for the game. The Lions won the game 40-0. That games marks the Lions largest margin of victory over the Packers in their 168 regular season game matchups.
Johnny Johnson
terry fox
96 yards by Bob Hoernschemeyer against the New York Yanks on November 23, 1950.
Ricky watters
Willie Parker (75 yards)
Tony Dorsett. Dorsett had a 99 yard run from scrimmage against the Minnesota Vikings on January 3, 1983.
Bill Osmanski.
Joseph Adahai had a 26 yard run
Willie Parker from the Pittsburgh Steelers in Super Bowl XL. 75 yards.
Walter Payton's longest rush from scrimmage was 76 yards against the Denver Broncos on October 16, 1978.
The longest rushing play from scrimmage was a 15 yard run by the Steelers' Willie Parker in the 3rd period. The run took the ball from the Cardinals' 20 yard line to their 5 yard line and gave the Steelers a 1st and goal. The Steelers wound up kicking a field goal on this drive.
Oregon State quarterback and Heisman Trophy winner Terry Baker has the longest TD, 99 yards in the 1963 Liberty Bowl against Villanova.