Serra High School in San Mateo, CA
Source: Wikipedia
I thought Long Beach Polytechnic, Long Beach, CA had produced the most professional athletics at least 26 that I am aware of.
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Someone said that Overbrook High where Wilt graduated is number one with 12.
I am sorry to let you know that DeMatha High School in Hyattsville , MD has produced 16.
1-Derick Whittenberg
2-John Austin
3-Adrian Dantley
4-Adrian Branch
5-Sidney Lowe
6-Joseph Forte
7-Keith Bogans
8-Sidney Lowe
9-Danny Ferry
10-Kenny Carr
11-Hawkeye Whitney
12.- Johnny Jones
13-Joe Kennedy.
Three more players who went to the NBA were on the 1965 team that gave Lewis Alcindor (Kareem Abdul Jabbar ) his onlt high school loss. They are
14 -Bobby Whitmore who played behind Alcindor and
15.Sid Catlett who played in front of him - both were 6'8".
16.Bernard Williams was a high flying guard on the same team and he won DC area player of the year that year and went on to La Salle and then the NBA. I can think of at least one more Jerod Mustaf played at Maryland and then in the Nba from 90' to 94'. That makes 17. Still many more were drafted like Aubrey Nash and Steve Hood, but do no show stats.
Notre Dame with 462 players including one of the best quarterbacks of all time Joe Montana
Sarasota High (FL) has produced 51 professional players, according to thebaseballcube.com