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Lou Brock is very much alive and active in the St. Louis community, as well as with the Cardinals organization. (btw: that's a picture of fellow Cardinals outfielder Curt Flood, with whom Brock played many years and together won 3 NL pennants and 2 World Series. Flood is pictured in his Cincinnati Reds cap during his rookie year.)
Yes. On June 2, 1941, Lou Gehrig succumbed to ALS (Amyotrophic lateral sclerosis), which is now often referred to as "Lou Gehrig's Disease".