their record is 9,824 wins and 9,548 losses
Roy Oswalt
70 wins and 92 losses.
Since the Houston franchise joined the National League in 1962 -- they are now in the American League -- the Cincinnati Reds have beaten the Colt .45s/Astros 443 times in 845 games.
cincinnati reds won their 10000 on 4/20/12
2
407
12,367
3 times
Eppa Rixey with 179 wins between 1921-1933.
As of right now the Atlanta franchise has 273 wins.
2,806
385