Two players were drafted out of SIU in the 1972 NFL Draft. Lionel Antoine was the 3rd overall pick in the draft, selected by the Chicago Bears and Tom Laputica was the 279th overall pick, selected by the San Francisco 49ers.
The University of Southern California with 11 players.
Howard Griffith of the University of Illinois scored 8 TDs in a game against Southern Illinois University on September 8, 1990.
Notre Dame
350
U of Southern Cal
UCLA and Kentucky are tied with 109 players drafted into the NBA as of October 2014. The University of North Carolina has had 105 drafted. The school that has had the most players drafted in the 21st century is Kentucky, with 22.
The two University of Michigan players who have been drafted 1st are:Tom Harrison, HB, 1941, Chicago BearsJake Long, T, 2008, Miami Dolphins
20
University of North Carolina and University of Southern California with 9 players each.
Illinois
Currently, the University of Southern California (commonly known as USC) has the most football players currently in the NFL, with 38 total players in the game.
Since 1994 when the 7 round draft was adopted. Ohio State had 14 players drafted (2004) Miami (2001) and USC (2006,2009) had 11 players drafted. Colorado (1994), Washington (1997), Penn State (1995) and Florida State (1995) had 10 players drafted. Source : University of Colorado Information Guide.