Exactly 438 Players.
Till 4/24/2011 by NBA.com
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The NBA originated in 1946 with 11 teams, and through a sequence of team expansions, reductions, and relocations, currently consists of 30 teams. If you had since the beginning, all the teams that exist now and the 450 players that are currently in the NBA for all those years, then there would have been over 30,000 players in NBA history. So the answer is obviously less, and also because most players play for many years, but probably somewhere in the ten thousands.