The size of teams in American football vary. The maximum number of people allowed on a team in the NFL is 53 once the season starts. There is no minimum, except there always must be 11 men on the field so a team has to have at least 11 players. In high school, there is no maximum number. The larger the number, the higher the division they are qualified as.
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There is always 22 people on the field at once in a football game. 11 from each team.
In American football, 11 men are on the field for each team, with 3 substitutions allowed per team.