It depends from where in the USA. However from USA the shortest was if from the west coast. For example from Los Angeles
to Kuala Lumpur Malaysia it is about 17 to 20 hours flight time. Most Airlines do make a stop in either Hong Kong, Tokyo
or Taipei so this would probably ad another 2 to 3 hours to the travel time.
In addition you would need to calculate the time you need to fly from the location in USA to LA.
Alternatively, there are flights from New York via Europe to Malaysia but they are longer and more expensive.
Soon, Malaysia Airlines will offer a direct flight using the new Airbus A380 which might be shorter.
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Los Angeles, CA (LAX) to Kuala Lumpur (KUL) Shortest Flight Duration 19 hours 35 mins