Yes. Manchester United beat Arsenal at Old Trafford 6-1 in 2001. Dwight Yorke scored a hat-trick, Roy Keane, Ole Gunnar Solskjaer and Teddy Sheringham also netted. Thierry Henry has briefly equalised for Arsenal.
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I believe it was Ipswich Town in 1981. An unbelievable game which also saw United keeper Gary Bailey save 3 penalties.
Actually, Southampton beat Man Utd 6-3 at the Dell in October 1996. Fergie was moaning at Full Time about how the players couldn't see each other wearing grey shirts.
The last team to beat Manchester United 6 - 0 was Ipswich Town, on March 1, 1980. Manchester United finished second in the league in that season, to Liverpool. Interestingly, all of the top seven teams lost their final Division One match of the 1979-80 sesaon.