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No, Cleopatra herself did not change history. The war between Octavian and Antony would have occurred whether there was a Cleopatra or not. Right now it's popular to extol Cleopatra and make her into something she was not. The current barrage of books about her try to make her into a brilliant politician, a world leader, a mathematician and even a scientist. However if you take an objective look at what we know of her, you'll find that she was a minor queen of a crumbling dynasty with absolutely no power except her personal ability to manipulate people. She herself did not change history; she just happened to be the tool that was used to bring about the last civil war of the Roman Republic.
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