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No. Through MLB games played on June 17, 2008 Babe Ruth is 87th on the MLB career strikeout list with 1,330. On the all time single season list, Babe Ruth is not in the MLB top 500. The most strikeouts he had in a season was 93 in 1923. He did lead the American League in strikeouts in 5 seasons (1918, 1923, 1924, 1927, 1928).
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