If you mean for one game the largest margin of victory has to be a game I saw in 1957 when the Reds beat the Cubs 22-2 in Crosley Field. Every starter (including the pitcher Hal Jeffcoat) had a home run except for Frank Robinson.
The Cincinnati Reds have the highest winning percentage against them. The Reds are 5-4 all time against the Yankees.
The Reds lead the all time series 5-4.
In 1977, the Cincinnati Reds had an 88-74 record.
In 2011, the Cincinnati Reds had a 79-83 record.
The Cincinnati Reds have won 5 World Series records.
In 2009, the Cincinnati Reds had a 78-84 record.
In 2012, the Cincinnati Reds had a 97-65 record.
Through May 22, 2011, the Reds have a 25-22 record.
70 wins and 92 losses.
Yes, Pete Rose did bet against his team, the Cincinnati Reds, which led to his ban from baseball in 1989.
The pitcher for the Cincinnati Reds in 1974 who faced Hank Aaron was Don Gullett. Gullett was a talented left-handed pitcher and part of the Reds' rotation during that season. He had the opportunity to pitch against Aaron as the legendary slugger pursued and ultimately broke Babe Ruth's home run record.
Ryan Freel with 5 against the Los Angeles Dodgers on July 27, 2005.