If you mean for one game the largest margin of victory has to be a game I saw in 1957 when the Reds beat the Cubs 22-2 in Crosley Field. Every starter (including the pitcher Hal Jeffcoat) had a home run except for Frank Robinson.
The Cincinnati Reds have the highest winning percentage against them. The Reds are 5-4 all time against the Yankees.
The Reds lead the all time series 5-4.
In 1977, the Cincinnati Reds had an 88-74 record.
In 2011, the Cincinnati Reds had a 79-83 record.
The Cincinnati Reds have won 5 World Series records.
In 2012, the Cincinnati Reds had a 97-65 record.
In 2009, the Cincinnati Reds had a 78-84 record.
Through May 22, 2011, the Reds have a 25-22 record.
70 wins and 92 losses.
Ryan Freel with 5 against the Los Angeles Dodgers on July 27, 2005.
5
Roy Oswalt