The first game involving the National Association was on 1871 May 4, with the Fort Wayne Kekiongas hosting the Cleveland Forest Citys.
However, there is some dispute on whether the NA was a true major "league."
On 1876 April 22, the Boston Red Stockings defeated the Philadelphia Athletics in the first game of the newly formed National League -- an organization that continue to this day.
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The first World Series Game was played on October 1, 1903 at the Huntington Avenue Baseball Grounds in Boston. The 16,242 fans in attendance saw the Pittsburgh Pirates beat the Boston Americans 7 - 3. The Boston Americans went on to beat the Pittsburgh Pirates 5 games to 3 in the best of nine series.
The first Major League All Star game played at Yankee Stadium was on July 11, 1939.
In 1951 the East (111) beat the West (94) at the Boston Garden( Boston, MA).
Ed Macauley of the Boston Celtics won the All Star Game MVP Title
The Arizona Diamondbacks are hosting the 2011 MLB All Star game.
It is scheduled to be held at Chase Field in Phoenix, Arizona, home of the Arizona Diamondbacks.