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Someone already answered this, but I think it was Pete Rose.

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Q: Who played in the most lost MLB games?
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Who holds the MLB record for most games played in a career?

Pete Rose, who played in 3,562 games in his career.

Which mlb player has played in the most regular season games ever?

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Check out the 'Consecutive Games Played Streaks' link on this page to see the 15 longest consecutive games played streaks in MLB history.

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Hall of Famer Walter Johnson of the Washington Senators pitched in the most 1-0 games in MLB history, won the most 1-0 games, and lost the most 1-0 games. In 64 1-0 games, he won 38 and lost 26.

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