Most Career Home Runs: Through October 22, 2016, Barry Bonds has the most career home runs with 762. Hank Aaron previously held the record with 755 home runs. Third on the career home run list is Babe Ruth with 714, and Alex Rodriguez, fourth with 696. Fifth on the list is Willie Mays with 660 home runs.
Barry Bonds has the most career home runs with 762.
Career statistic: Home runs - 536
Babe Ruth had 714 career home runs.
Frank Robinson hit 586 career home runs.
Rafael Palmeiro with 569 career home runs.
As of September 6, 2012, Thome has 611 career home runs.
Hank Aaron hit 755 career home runs.
Through 2010, Nick Swisher has 162 home runs in his career.
Jose bautista has hit about 269 home runs in his career
Jeff Bagwell hit 449 career home runs.
Rafael Palmeiro hit 569 career home runs.