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The Phosphogen System
Skeletal muscle uses large amounts of ATP during active contraction. Skeletal muscle can produce limited amounts of ATP from the breakdown of stored phosphocreatine. As ATP is used and ATP levels decrease, phosphocreatine is used to make ATP from ADP. When the cell is resting and ATP levels increase due to aerobic glucose catabolism, phosphocreatine is produced from ATP and creatine. This mechanism can produce 1 ATP for every molecule of phosphocreatine present. Muscle cells normally have enough phosphocreatine to produce ATP for several minutes at rest but only 10-15 seconds during exercise.
Phosphagens, also known as macroergic compounds, are high energy storage compounds, also known as high-energy phosphate compounds, chiefly found in muscular tissue in animals.
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