The record for most appearances by a pitcher in the World Series is held by Whitey Ford, who played in 22 games. Ford spent his entire 16-year career with the New York Yankees and is widely regarded as one of the greatest pitchers in World Series history.
Whitey Ford has the most career World Series losses by a pitcher with 8.
Nobody.
San Francisco Giants ace Tim Lincecum was the winning pitcher in Games 1 and 5 of the 2010 World Series against the Texas Rangers.
Randy Johnson won three World Series games in the 2001 World Series to help beat the New York Yankees 4 games to 3.
Matt Cain
Tim Lincecum.
Yogi Berra played in the most World Series games with 75.
George Frazier was the losing pitcher in Games 3, 4, and 6 of the 1981 World Series, won by the Los Angeles Dodgers over the Yankees 4 games to 2.
Bob Gibson holds the World Series record for most strikeouts by a pitcher in a World Series (35 in 1968) and most strikeouts by a pitcher in a single game (17 in Game 1 of the 1968 WS). He is tied for most games won by a pitcher in a World Series (3 in 1967).
Deacon Phillipe of the Pittsburgh Pirates threw 5 complete games in the 1903 World Series against the Boston Americans.
John Wetteland of the New York Yankees in the 1996 World Series against the Atlanta Braves.
As far as the World Series goes, that was Christy Mathewson of the New York Giants in 1905. The Giants won the Series, 4 games to 1, over the Philadelphia Athletics. Not only did Mathewson win three games, he pitched three shutouts. He is the only pitcher in World Series history to throw three shutouts in one Series.