What is Coenzyme A?
Photosynthetic plants convert light energy into chemical energy. Using their photosynthetic products (ATP, NAD(P)H, and carbon skeleton), plants have unique ability to assimilate soil and atmospheric elements into compounds usable by human and animals. Photosynthesis provides carbon precursors and cofactors for many of the essential plant biosynthetic pathways, of which coenzyme A (CoA) is one of their products.
Function of Coenzyme A in Plants
Coenzyme A is a cofactor for 4% of the enzymes in plants. Coenzyme-a is converted into acyl-coenzyme-A (CoA), mainly acetyl-coenzyme-A (CoA), upon reaction with carbohydrate catabolites. Acetyl-coenzyme-A (CoA) is a key substrate in important metabolisms such as citric acid cycle (TCA cycle), fatty acid, some amino acids, flavonoid, wax, isoprenoid, lignin synthesis and storage lipid degradation. These biochemical pathways generate intermediate metabolites that play a role in the adaptation of the plant to changing environmental conditions, defense against pests, nutritional value, pigment and structural component synthesis. Acetyl-coenzyme-a (CoA) also mediates synthesis of secondary metabolites (natural products) of pharmaceutical and industrial significance.
Coenzyme A is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester, such as acetyl-CoA) as a substrate.
The products of acetyl CoA formation from a molecule of pyruvate are acetyl CoA, NADH, and carbon dioxide. This process occurs during the mitochondrial pyruvate dehydrogenase complex reaction, where pyruvate is converted to acetyl CoA by a series of enzymatic reactions.
Citric acid and Coenzyme ASH (reduced CoA).
In the reaction that forms acetyl-CoA, the molecule that joins is pyruvate. This reaction occurs during the conversion of pyruvate to acetyl-CoA in the mitochondria.
COA stands for Certificate of Authenticity.
Fatty acids, cholesterol, and ketone bodies can be made from acetyl CoA molecules.
The enzyme CoA catalyzes the reaction between pyruvic acid and CoA to form acetyl-CoA in the mitochondria. This is a crucial step in the conversion of glucose to energy in the form of ATP through the process of cellular respiration. Acetyl-CoA enters the citric acid cycle to produce more ATP.
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COA is an acronym that stands for Certificate of Authenticity.
There are four carbons in succinyl CoA.
Acetyl CoA
The products of acetyl CoA formation from a molecule of pyruvate are acetyl CoA, NADH, and carbon dioxide. This process occurs during the mitochondrial pyruvate dehydrogenase complex reaction, where pyruvate is converted to acetyl CoA by a series of enzymatic reactions.
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Acetyl-CoA enters the Krebs cycle and is generated from the last compound in glycolysis, pyruvate.
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Citric acid and Coenzyme ASH (reduced CoA).