No, Sean Payton is not related to or a part of Peyton Manning's family. Both just happen have a connection to the New Orleans Saints and have they same pronunciation in names though spelled differently. (Peyton, Payton)
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sean penn
Yes and no. Sean Murray's mom is Vivienne is Donald Bellisario's fourth wife thus making Sean to be Donald's stepson. Since Patrick is Donald's nephew and Sean is Donald's stepson, yes they are family. But they are not blood related.
Seans Car
Sean Flynn is Chase from Zoey 101.
Sean McGee? Sean Murray OR Tim McGee maybe?