The San Marino Grand Prix in May 1994 was the saddest Grand Prix. Roland Ratzenberger was killed the day before the race in qualifying, and Ayrton Senna was killed during the race.
The second saddest Grand Prix is the 1986 German Grand Prix, in which Niki Lauda crashed on Lap 1 and was nearly burned to death.
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Last year, in 2011, the coldest Grand Prix was the German Grand Prix, with a track temperature of 14oC
Probably the 1961 Italian Grand Prix, because the collision between Jim Clark and Wolfgang von Trips resulted in von Trips as well as 14 spectators being killed.