Since 1946, Oklahoma is the winningest program either way you look at it. Leading the list in total wins is Oklahoma with 514. Nebraska, Penn State, and Texas are tied at second with 494. Oklahoma also leads the winning percentage list at .755. Ohio State is second at .743.
USC is the winningest football school since 2001
Tennessee
nebraska
Virginia Tech
Florida State University
1. Boise State
Mount Union College Grand Valley State Oklahoma University
Boise State has the best record (100-11) since 2002 (including 2002).
Michigan
boise state usc florida oklahoma michigan ohio state georgia oregon auburn texas
Since 2000, Duke and North Carolina are two of the top winningest college basketball programs. Other top ten winningest programs include Kansas, UConn, Florida, Michigan State, Maryland, Syracuse, UCLA, and UT.
update 11/29/2008 with UF victory today over FSU Florida Gators (187-51-1) Florida State Seminoles (186-51-1)