* Jon Lester, Came back after being diagnosed with a rare form of non-Hodgkin's lymphoma in 2006 to win the clinching Game 4 of the 2007 World Series.
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1970 Tony Conigliaro
2002 * José Rijo ** Came back after five years out of baseball with serious elbow injuries
Edward Easely.
1997 - Tony Clark and Bobby Higginson (tie)
Brett Favre did of course!