Randy Johnson.
Johnson, pitching for the San Francisco Giants, won his 300th game on June 4, 2009 against the Washington Nationals.
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Randy Johnson has the most strikeouts by a left handed pitcher. He also has the second most strikeouts all-time and over 300 wins.
As best I can tell it's Ryan Howard. At the end of the 2012 season, he had hit 300 home runs and had played in 1098 MLB games. This beats Alex Rodriguez (youngest player to reach 300), Mark McGwire (fewest AB and PA to reach 300), and Babe Ruth (took over 1150 games to reach 300).
Francisco Liriano played in 22 games at pitcher for the Minnesota Twins in 2012, starting in 17 of them. He played for a total of 300 outs, equivalent to 11.11 9-inning games. He made 3 putouts, had 19 assists, and committed no errors, equivalent to 0 errors per 9-inning game. He had 2 double plays.
Dave Otto played in 18 games at pitcher for the Cleveland Indians in 1991, starting in 14 of them. He played for a total of 300 outs, equivalent to 11.11 9-inning games. He made one putout, had 16 assists, and committed one error, equivalent to .09 errors per 9-inning game. He had no double plays.
Brian Barnes played in 52 games at pitcher for the Montreal Expos in 1993, starting in 8 of them. He played for a total of 300 outs, equivalent to 11.11 9-inning games. He made 3 putouts, had 15 assists, and committed no errors, equivalent to 0 errors per 9-inning game. He had one double play.