As of the 2007 season, the NFL record for TD passes in a game is 7 and has been done by five QBs:
1) Sid Luckman, Chi. Bears vs. N.Y. Giants, Nov. 14, 1943
2) Adrian Burk, Philadelphia vs. Washington, Oct. 17, 1954
3) George Blanda, Houston vs. N.Y. Titans, Nov. 19, 1961
4) Y.A. Tittle, N.Y. Giants vs. Washington, Oct. 28, 1962
5) Joe Kapp, Minnesota vs. Baltimore, Sept. 28, 1969
6) Brett farve
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Through the 2008 season, that is Drew Bledsoe of the 1994 New England Patriots who threw 694 passes.
Warren Moon of the 1991 Houston Oilers is second all time at 655.
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brett favre
Peyton Manning
It is 50 by Tom Brady of the New England Patriots in the 2007 season. Manning is second and Marino 3rd.
The 2004 season was Roethlisberger's first season in the NFL. He played in 14 games, completed 196 of 295 passes for 2,621 yards, threw 17 TD passes and 11 INTs, and ran the ball 56 times for 144 yards and 1 TD.