Don Shula
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As best I can tell it's Ryan Howard. At the end of the 2012 season, he had hit 300 home runs and had played in 1098 MLB games. This beats Alex Rodriguez (youngest player to reach 300), Mark McGwire (fewest AB and PA to reach 300), and Babe Ruth (took over 1150 games to reach 300).
the First 300
the first cart was invented in about 300 b.c
Ethelda Bleibtrey in 100 meter freestyle at the 1920 Games in Antwerp. She also won gold in 300 meter freestyle and 4x100 meter freestyle relay at the 1920 Games.
NFL playbooks can have as many plays as the coach and team decide. On average, an NFL team playbook can have up to 300 plays even if they all are not used.