In MLB, that was Derek Jeter of the Yankees who hit a home run in the 6th inning of Game 6 of the 2000 World Series.
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Dan Uggla of the Florida Marlins hit the last home run in Shea Stadium in the 8th inning of the final game of the 2008 season.
josh hamilton
Chito Martinez.Martinez hit the last home run in the 6th inning of the next to last game at Memorial Stadium played on October 5, 1991 against the Detroit Tigers.
Stan musial
Never