March 30th, 2000 found the Yankees at Enron Field in Houston, set to play the inaugural exhibition game at the new retractable-roof dome against the Astros. When the Astrodome first opened in 1965, the Astros had also faced the Yankees for an exhibition game to open their new stadium. Back on April 9, 1965, in that game, Mickey Mantle became the first player ever to hit a home run in the Dome. On March 30,2000, Ricky Ledee pinch hitting for Clemens, promptly hit the first home run to leave Enron Field.
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The first home run hit at Jacobs Field was April 4, 1994 by Eric Anthony of the Settle Mariners.
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Russ Davis of the Mariners hit the first home run Safeco Field history in the 5th inning of the game against the San Diego Padres on July 17, 1999.
That was Cecil Fielder of the Detroit Tigers in the 3rd inning of the first regular season game played in U.S. Cellular Field on April 18, 1991.
That was Michael Tucker in the 3rd inning of the first game played at Turner Field, April 4, 1997. The Braves won 5-4.