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June 10, 1960, Cincinnati Reds catcher Dutch Dotterer hit a grand slam home run off Koufax in the top of the 2nd inning, at the LA Coliseum, scoring Lee Walls, Willie Jones and Gus Bell, to give the Reds a 4-0 lead. After walking the next batter, opposing pitcher Bob Purkey, Ed Palmquist replaced Koufax. The Dodgers lost 4-3, Purkey was credited with the win, to raise his record to 5-2, while Koufax's W-L record fell to 1-8. Koufax finished the 1960 year with an 8-13 record (his last sub .500 pitching season).

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