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As of the 2008 season, that would be the New York Yankees who have played the Cardinals five times in the World Series (1926, 1928, 1942, 1943, 1964). The Cardinals have played the Detroit Tigers and Boston Red Sox each 3 times in the WS. They've played the Philadelphia Athletics twice in the WS. They've played the St. Louis Browns, Milwaukee Brewers, Kansas City Royals, and Minnesota Twins once in the WS.

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