Mike Lowell, of the Boston Red Sox, hit a one-run home run off New York Yankees pitcher Joba Chamberlain on September 16, 2007. http://www.Baseball-reference.com/play-index/event_hr.cgi?n1=chambjo03&type=p
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Joe Niekro, then playing for the Houston Astros, hit his only MLB home run off of brother Phil, then playing for the Atlanta Braves, on May 29, 1976.
Through games played on June 30, 2009 only three batters have hit two home runs off of Rivera ... Edgar Martinez, Rafael Palmiero, and Aubrey Huff. The Baltimore Orioles have hit the most home runs off of him (10).
Dustin Pedroia, as the first batter in the 2007 World Series, hit a home run off of Jeff Francis of the Colorado Rockies. That has been done once before, in the 1969 World Series when Don Buford of the Baltimore Orioles led off the Series with a home run off of Tom Seaver of the New York Mets. There have been many players to hit a home run in the first game of the World Series, the first being Jimmy Sebring of the Pittsburgh Pirates in the 1903 World Series. But Pedroia and Buford are the only two players that hit home runs in the first at bat of a World Series.
3 ... June 1, 2001 at Coors Field, July 19, 2003 at PacBell, and April 13, 2007 at PNC Park.