Here's a list as of the start of the 2008 season:
CAREER
EARNED RUNS ER
1 Cy Young 2146
2 Phil Niekro 2012
3 Don Sutton 1914
4 Nolan Ryan 1911
5 Pud Galvin 1895
6 Gus Weyhing 1867
7 Steve Carlton 1864
8 Gaylord Perry 1846
9 Red Ruffing 1833
10 Bert Blyleven 1830
11 Warren Spahn 1798
12 Early Wynn 1796
13 Robin Roberts 1774
14 Tommy John 1749
15 Jim Kaat 1738
16 Earl Whitehill 1726
17 Roger Clemens 1707
18 Frank Tanana 1702
19 Ted Lyons 1696
20 Tom Glavine 1695
21 Ferguson Jenkins 1669
22 Greg Maddux 1665
23 Bobo Newsom 1664
24 Jamie Moyer 1662
25 Kid Nichols 1660
26 Jack Morris 1657
27 Sad Sam Jones 1656
28 Dennis Martinez 1643
29 Burleigh Grimes 1636
30 Charlie Hough 1582
31 David Wells 1578
32 Eppa Rixey 1572
33 Tony Mullane 1537
34 Tom Seaver 1521
35 Waite Hoyt 1500
36 Jerry Reuss 1483
37 Grover C Alexander 1476
38 Tim Keefe 1472
39 Kenny Rogers 1458
40 Adonis Terry 1456
41 Jack Powell 1450
T42 Mickey Welch 1447
T42 Mel Harder 1447
44 Bob Friend 1438
T45 Jack Quinn 1433
T45 Jerry Koosman 1433
47 Joe Niekro 1431
48 Red Faber 1430
49 Herb Pennock 1428
50 Walter Johnson 1424
51 John Clarkson 1417
52 Doyle Alexander 1406
53 Paul Derringer 1401
54 Mickey Lolich 1390
55 Bump Hadley 1389
T56 Bob Feller 1384
T56 George Uhle 1384
58 Mike Mussina 1383
T59 Randy Johnson 1381
T59 Mike Moore 1381
61 Chick Fraser 1371
T62 Chuck Finley 1366
T62 Jim Bunning 1366
64 Old Hoss Radbourn 1348
65 Mike Torrez 1340
66 Lefty Grove 1339
T67 Rick Reuschel 1330
T67 Ted Breitenstein 1330
69 Brickyard Kennedy 1329
70 Pink Hawley 1326
71 Bobby Witt 1324
72 Curt Simmons 1318
73 Mark Langston 1306
74 Mike Morgan 1303
75 Jesse Haines 1298
76 Tom Zachary 1295
77 Amos Rusie 1287
78 Danny Darwin 1286
T79 Willis Hudlin 1281
T79 Rick Wise 1281
81 Luis Tiant 1280
82 Bert Cunningham 1279
83 Dennis Eckersley 1278
84 Charlie Root 1274
T85 Claude Osteen 1268
T85 John Burkett 1268
T87 Tim Wakefield 1262
T87 Terry Mulholland 1262
T89 Bob Gibson 1258
T89 Jim Perry 1258
91 Freddie Fitzsimmons 1257
92 Al Orth 1256
T93 Curt Schilling 1253
T93 Jim Palmer 1253
95 Hooks Dauss 1250
96 Catfish Hunter 1248
T97 Lew Burdette 1246
T97 Clark Griffith 1246
99 Murry Dickson 1240
100 Larry Jackson 1233
101 Red Ehret 1229
102 Bill Hutchison 1228
103 Rube Walberg 1224
T104 Kid Carsey 1223
T104 Rick Sutcliffe 1223
106 John Smoltz 1221
T107 Vida Blue 1211
T107 Orel Hershiser 1211
109 Larry French 1206
110 Joe Bush 1205
111 Frank Dwyer 1204
T112 Milt Pappas 1203
T112 Scott Erickson 1203
114 Jim Slaton 1202
115 Billy Pierce 1201
T116 Jack Stivetts 1199
T116 Mike Flanagan 1199
118 Red Donahue 1194
T119 Bob Welch 1191
T119 Danny MacFayden 1191
121 Carl Hubbell 1188
T122 Lee Meadows 1185
T122 Kevin Brown 1185
124 Camilo Pascual 1183
T125 Steve Trachsel 1182
T125 Jim Clancy 1182
T127 Jouett Meekin 1177
T127 Wes Ferrell 1177
T129 Howard Ehmke 1175
T129 Frank Viola 1175
131 Eddie Plank 1174
132 Bob Forsch 1169
133 Vic Willis 1167
134 Guy Bush 1166
135 Dutch Leonard 1162
136 Dolf Luque 1161
137 George Mullin 1156
138 Jim McCormick 1155
T139 Jim Whitney 1154
T139 Dave Stewart 1154
T139 Fernando Valenzuela 1154
142 Brad Radke 1150
143 Pedro Astacio 1140
144 Bucky Walters 1139
145 Kevin Gross 1137
146 Christy Mathewson 1133
T147 Rube Marquard 1130
T147 Tim Belcher 1130
T147 Tom Candiotti 1130
150 Bill Lee 1127
T151 Silver King 1126
T151 Juan Marichal 1126
153 Don Drysdale 1124
154 Tommy Bridges 1122
T155 Charlie Buffinton 1120
T155 Bill Sherdel 1120
T157 Wilbur Cooper 1119
T157 Livan Hernandez 1119
T159 Bill Gullickson 1118
T159 Vern Law 1118
161 David Cone 1115
162 Ken Holtzman 1111
163 Steve Renko 1107
T164 Dave Stieb 1106
T164 Andy Benes 1106
T164 Bob Knepper 1106
167 Aaron Sele 1102
168 Kevin Tapani 1094
169 Scott Sanderson 1093
T170 Win Mercer 1091
T170 Dwight Gooden 1091
172 Paul Splittorff 1082
173 Jimmy Ring 1079
T174 Floyd Bannister 1078
T174 Kevin Appier 1078
T174 Jaime Navarro 1078
177 Andy Pettitte 1077
178 General Crowder 1072
T179 Dazzy Vance 1068
T179 Pedro Ramos 1068
T179 Esteban Loaiza 1068
182 Milt Gaston 1064
183 Jeff Suppan 1060
184 Jim Lonborg 1056
185 Joe Coleman 1055
186 Frank Killen 1054
T187 Doug Drabek 1052
T187 Bruce Hurst 1052
T187 Vern Kennedy 1052
T190 Ray Sadecki 1051
T190 Mark Baldwin 1051
192 Red Lucas 1048
193 Todd Stottlemyre 1042
T194 Rick Rhoden 1036
T194 Si Johnson 1036
T194 Sid Hudson 1036
197 Woody Williams 1031
T198 Bill Dinneen 1029
T198 Larry Benton 1029
200 Ned Garver 1027
201 Sadie McMahon 1026
202 Bob Lemon 1024
203 Jon Lieber 1022
204 Mike Caldwell 1020
205 Bob Buhl 1019
206 Jack Russell 1017
T207 Hal Newhouser 1016
T207 Ron Darling 1016
T207 Joe McGinnity 1016
T207 Clarence Mitchell 1016
211 Ray Burris 1015
212 Stan Bahnsen 1013
T213 Al Leiter 1010
T213 Jimmy Key 1010
T213 Woodie Fryman 1010
216 Virgil Trucks 1009
217 Bob Shawkey 1008
T218 Rudy May 1007
T218 Kid Gleason 1007
220 Eddie Rommel 1006
221 Claude Passeau 1003
222 Steve Rogers 1001
223 Elton Chamberlin 999
224 Joe Nuxhall 998
225 Bill Dietrich 997
T226 Burt Hooton 996
T226 Pat Hentgen 996
228 Tommy Thomas 995
229 Darryl Kile 992
230 Stan Coveleski 990
231 Mike McCormick 986
232 Mudcat Grant 985
233 Lon Warneke 984
234 Bob Smith 983
235 Dave McNally 982
236 Javier Vazquez 981
237 Charles Nagy 980
T238 Carl Mays 979
T238 Mike Cuellar 979
T238 Dizzy Trout 979
241 Mark Gubicza 978
T242 Syl Johnson 977
T242 Bob Rush 977
T244 Charlie Getzien 976
T244 Jack Taylor 976
246 Ed Brandt 974
247 Dick Ruthven 970
248 Whitey Ford 967
249 George Blaeholder 966
250 Wilbur Wood 965
T251 Elden Auker 964
T251 Art Nehf 964
253 Herm Wehmeier 961
254 Harry Staley 959
255 Greg Swindell 957
256 Schoolboy Rowe 955
257 Ron Reed 953
T258 Bret Saberhagen 952
T258 Charlie Leibrandt 952
T260 Mike Krukow 949
T260 Jack Billingham 949
T260 Scott McGregor 949
T263 Guy Hecker 944
T263 Ed Whitson 944
265 Ad Gumbert 942
T266 Urban Shocker 941
T266 Ray Benge 941
268 Matt Kilroy 939
269 John Candelaria 935
270 Red Ames 934
271 George Earnshaw 933
272 Walt Terrell 931
T273 Lefty Gomez 929
T273 Jeff Fassero 929
275 Stump Wiedman 928
276 Johnny Klippstein 927
277 Hal Schumacher 926
278 Johnny Podres 925
279 Don Cardwell 924
T280 Danny Jackson 923
T280 Hideo Nomo 923
282 Thornton Lee 921
283 Bill Doak 920
284 Jesse Barnes 918
T285 Jose Lima 917
T285 Fritz Ostermueller 917
T287 Chuck Stobbs 916
T287 Mike Hampton 916
T289 Babe Adams 915
T289 Allie Reynolds 915
291 Milt Wilcox 913
T292 Kirk Rueter 911
T292 Dan Petry 911
294 Bobby Mathews 910
295 Pete Donohue 909
T296 Sam Gray 906
T296 Tom Gordon 906
T296 Alex Kellner 906
299 Long Tom Hughes 905
300 Harvey Haddix 901
301 Bartolo Colon 899
T302 Dennis Leonard 898
T302 Mike Witt 898
T302 Jeff Weaver 898
305 Mike Boddicker 897
306 Will White 896
307 Mark Gardner 894
308 Rick Honeycutt 893
T309 Denny Neagle 891
T309 Bob Purkey 891
T309 Ken Hill 891
T309 Bob Caruthers 891
T309 Jack Fisher 891
314 Dick Ellsworth 890
T315 Chris Short 886
T315 Dave Burba 886
T315 Wild Bill Donovan 886
318 Denny Galehouse 885
T319 Nig Cuppy 884
T319 Curt Davis 884
321 Hal Carlson 883
T322 Dave Roberts 882
T322 Harry Gumbert 882
324 Sam McDowell 879
325 Mel Stottlemyre 878
326 Bud Black 876
T327 Joe Dobson 874
T327 Ron Guidry 874
329 Rich Dotson 872
330 Ed Lopat 869
331 Eric Milton 868
332 Jason Schmidt 867
T333 Ron Kline 866
T333 Rick Mahler 866
Pitcher Jamie Moyer, who played in the major leagues until he was 49 years old in 2012, holds the record for most home runs yielded with 522. On June 27, 2010, as a member of the Philadelphia Phillies, he surpassed the record of the late Robin Roberts, who gave up 505 homers during his career.
Most Career Home Runs: Through October 22, 2016, Barry Bonds has the most career home runs with 762. Hank Aaron previously held the record with 755 home runs. Third on the career home run list is Babe Ruth with 714, and Alex Rodriguez, fourth with 696. Fifth on the list is Willie Mays with 660 home runs.
So far in the 2010 Major League Baseball season Kevin Millwood of the Baltimore Orioles has given up the most home runs with 20. There are three pitchers who have given up 19 home runs.
Warren SpahnWarren Spahn gave up 18 home runs to Willie Mays.
For a career that would be Hank Aaron with 755.
Jamie Moyer gave up 511 home runs in his career, more than any other MLB pitcher.
Barry Bonds has the most career home runs with 762.
Babe Ruth has the most career home runs as a Yankee with 659.
Tiger Woods
Mickey Mantle has the most career World Series home runs with 18.
=== === === ===
Rafael Palmeiro with 569 career home runs.
Pitcher Jamie Moyer, who played in the major leagues until he was 49 years old in 2012, holds the record for most home runs yielded with 522. On June 27, 2010, as a member of the Philadelphia Phillies, he surpassed the record of the late Robin Roberts, who gave up 505 homers during his career.
Most Career Home Runs: Through October 22, 2016, Barry Bonds has the most career home runs with 762. Hank Aaron previously held the record with 755 home runs. Third on the career home run list is Babe Ruth with 714, and Alex Rodriguez, fourth with 696. Fifth on the list is Willie Mays with 660 home runs.
Slugger Barry Bonds holds the record for the most home runs in a career. In the course of his career, he blasted 762 out of the park.
Brad Hodge with 2228 runs.
Willie Stargell has the most career Homeruns as a Pirate with 475 Homeruns in his career as a Pirate.