1869 The Red Stockings
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Click on the 'First MLB Game' link on this page to read about the first game in MLB history and to see who played in it.
The Cincinnati Reds play the first game of every season in Cincinnati. This is because the Cincinnati Red Stockings became the first professional team in baseball history back in the 1870's, and have traditionally received the right to play the season opener at home ever since.
The Cubs play against the Cincinnati Reds in Cincinnati at 11:35 AM Central time.
Woodrow Wilson.
Cincinnati Reds swept the Okland Athletics 4-0.