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In MLB, the most no-hitters thrown in a regular season is two and has been done by four pitchers ...
1) Johnny Vander Meer of the 1938 Cincinnati Reds - June 11 against the Boston Braves and June 15 against the Brooklyn Dodgers.
2) Allie Reynolds of the 1951 New York Yankees - July 12 against the Cleveland Indians and September 28 against the Boston Red Sox.
3) Virgil Trucks of the 1952 Detroit Tigers - May 15 against the Washington Senators and August 25 against the New York Yankees.
4) Nolan Ryan of the 1973 California Angels - May 15 against the Kansas City Royals and July 15 against the Detroit Tigers.
Roy Halladay of the Philadelphia Phillies also threw two no-hitters in 2010, one in the regular season (May 29 against the Florida Marlins) and one in the postseason (October 5 against the Cincinnati Reds in Game 1 of the NLDS). The May 29 no-hitter was a perfect game.
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