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That would be John Coleman of the 1883 Philadelphia Quakers who lost 48 games (w/l record was 12-48). Since 1900, the most losses in a season by a pitcher is 29 by Hall of Famer Vic Willis of the Boston Braves in 1905 (w/l record was 12-29). Since 1950, the most losses in a season by a pitcher is 24 by Roger Craig of the 1962 New York Mets (w/l record was 10-24) and Jack Fisher of the 1965 New York Mets (w/l record was 8-24).

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