Gene Lipscomb, a defensive lineman for the Rams, Colts, and Steelers between 1953-1962, was known as Big Daddy. He lost his life to a heroin overdose at the age of 31 in 1963.
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The "Big M" was Frank Mahovlich.
Glen Robinson
Oscar Robertson, Hall of Fame guard for the Royals and Bucks between 1960-1974, went by the nickname of Big O.
Andres Galarraga, first baseman for several teams between 1985-2004, was known as the Big Cat.
Hall of Famer Elvin Hayes, who played for the Rockets and Bullets between 1968-1984, went by the nickname of Big E. Or as we used to yell when he would hit one of those 14 foot turn around jumpers, EEEEEEEEEEEEEEEEEEEEEEE.