Lou Gehrig led Major League Baseball in home runs three times during his career.
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Lou Gehrig hit his last home run, number 493 on September 27, 1938, at Yankees Stadium, against Washington Senators pitcher Dutch Leonard in the bottom of the 4th inning.
Lou Gehrig hit his first major league home run on September 27, 1923. It was against the Boston Red Sox at Fenway Park.
Mickey Mantle hit his first home run on May 1, 1951, batting left handed at Comiskey Park vs. Chi White Sox Right handed pitcher Randy Gumpert.
Lou Gehrig's Major League debut was on June 15, 1923 as a pinch hitter. His consecutive game streak began on June 2, 1925, when he started at first base for the injured Wally Pipp.
Through the 2008 season, that is Mickey Mantle with 536.
Mickey Mantle
Chase Utley of the Philadelphia Phillies with 7 career World Series home runs.
In MLB, that was Babe Ruth who struckout for the 1000th time in the 1930 season. Ruth was the MLB leader in career strikeouts (with 1330) until 1964 when he was surpassed by Mickey Mantle.
The first home run in MLB history was by Ezra Sutton of the Cleveland Forest Citys on May 8, 1871 against the Chicago White Stockings in the National Association. Sutton hit a second home run in the game to be the player to hit the first and second home runs in MLB history.