Rube Bressler debuted on April 24, 1914, playing for the Philadelphia Athletics at Shibe Park; he played his final game on July 17, 1932, playing for the St. Louis Cardinals at Sportsman's Park IV.
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Rube Parnham debuted on September 20, 1916, playing for the Philadelphia Athletics at Shibe Park; he played his final game on September 24, 1917, playing for the Philadelphia Athletics at Shibe Park.
Ruben Rodriguez debuted on September 15, 1986, playing for the Pittsburgh Pirates at Three Rivers Stadium; he played his final game on October 1, 1988, playing for the Pittsburgh Pirates at Three Rivers Stadium.
His father Victor Rodriguez
Ruben Gomez debuted on April 17, 1953, playing for the New York Giants at Polo Grounds IV; he played his final game on May 2, 1967, playing for the Philadelphia Phillies at Connie Mack Stadium.
Ruben Rivera debuted on September 3, 1995, playing for the New York Yankees at Yankee Stadium II; he played his final game on May 28, 2003, playing for the San Francisco Giants at PacBell Park.
Ruben Amaro played in 3 games at designated hitter for the Cleveland Indians in 1995, starting in none of them. , equivalent to 0 errors per game (estimate based on total games played in).
Ruben Sierra played in 7 games at designated hitter for the Oakland Athletics in 1995, starting in none of them. , equivalent to 0 errors per game (estimate based on total games played in).