Luke Appling debuted on September 10, 1930, playing for the Chicago White Sox at Comiskey Park; he played his final game on October 1, 1950, playing for the Chicago White Sox at Comiskey Park.
Luke Easter debuted on August 11, 1949 and played his final game on May 4, 1954.
Matt Luke debuted on April 3, 1996, playing for the at ; he played his final game on September 30, 1999, playing for the Anaheim Angels at Edison International Field.
Dusty Hughes debuted on September 6, 2009, playing for the Kansas City Royals at Kauffman Stadium; he played his final game on May 27, 2011, playing for the Minnesota Twins at Target Field.
Luke Walker debuted on September 7, 1965, playing for the Pittsburgh Pirates at Forbes Field; he played his final game on October 1, 1974, playing for the Detroit Tigers at Tiger Stadium.
A left handed, preachers kid who's father doesn't want Luke to play baseball or be a lefty. But Luke is a child prodigy when it comes to baseball (pitching to be exact)
NFL player John Hughes played for Cincinnati.
NFL player Kofi Hughes played for Indiana.
Luke Allen debuted on September 10, 2002 and played his final game on July 17, 2003.
Luke Appling debuted on September 10, 1930 and played his final game on October 1, 1950.
Luke Boone debuted on September 9, 1913 and played his final game on September 2, 1918.
Luke Carlin debuted on May 10, 2008 and played his final game on May 30, 2012.
Luke Easter debuted on August 11, 1949 and played his final game on May 4, 1954.
NFL player Robert Hughes played for Notre Dame.
NFL player Kevin Hughes played for Southeastern Louisiana.
NFL player Montori Hughes played for Tennessee-Martin.
Luke Hughes played in 2 games at third base for the Minnesota Twins in 2010, starting in all of them. He played for a total of 48 outs, equivalent to 1.78 9-inning games. He made no putouts, had 4 assists, and committed no errors, equivalent to 0 errors per 9-inning game. He had one double play.
NBA player Luke Babbitt played for Nevada.