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Mark Reynolds of the Arizona Diamondbacks who struck out for the 700th time in his 516th game.
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The longest Opening Day game in major league history was a 15-inning affair played at Cleveland Stadium on April 19, 1960. The Detroit Tigers defeated the Cleveland Indians 4-2.
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Although the definition of "major league" has been argued, present day MLB, as well as the Hall of Fame, define the first "major" league as the National League founded in 1876. The link below describes the first game played in that league, on April 22, and mentions that Jim O'Rourke got the first hit in that game.