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The database I use only has game logs back to 1954, and since then, only 17 times has a team hit at least 8 home runs in a game. I checked the box scores for each, and here is what I came up with:
About half the time if a team hits at least 8 home runs, two more more players have a multihomer game
Twice in an 8-homer game, three players have had multihomer games:
9/14/87 - TOR @ BAL - Ernie Whitt(3), George Bell and Rance Mulliniks (2 each)
8/18/56 - MIL @ CIN - Bob Thurman (3), Ted Kluszewski and Frank Robinson (2 each).
None of these games featured 4 multihomer players.
So, to answer your question, no - at least not since 1954.
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