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The 1906 Chicago Cubs had the best winning percentage over the course of an entire season, going 116-36 (.764) In the modern era, (162 game schedule) the 2001 Seattle Mariners own the regular season crown. They went 116 and 46 (.716). Despite their record setting regular seasons, neither of these teams won the world series.

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As far as MLB goes, through the games played on July 24, 2008 that would be the New York Yankees who have a .561 all time winning percentage. Their all time record is 9439-7207. The team with the most all time wins is the Giants with 10,227. The Cubs are next with 10,045.

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Q: What team has the best cumulative record in baseball?
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