Ed Reed of the Baltimore Ravens with 9.
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Through the 2008 season in the NFL, that is Brett Favre with 310 career interceptions.
based on calculations from the 2008 season, the average number of interceptions thrown by starting NFL quarterbacks is .83.
The NFL player with the most career interceptions (81) is Paul Krause, who played for Washington and Minnesota in the 1960s and 70s. He had a 15-year career in the NFL.
Barry Sanders
As of the end of the 2011 NFL season and playoffs, the player with the most interceptions against Aaron Rodgers is Brian Urlacher of the Chicago Bears with three. Three other players have had multiple interceptions against Rodgers during his career, with two each: Lance Briggs (Chicago), Elbert Mack (Tampa Bay), and Jason David (New Orleans). David is the only player to have more than one interception against Rodgers in the same game.Rodgers' 41 career interceptions (including playoffs) by position group: 27 by defensive backs, 12 by linebackers, and two by defensive linemen.