The 'Big Train' was Hall of Fame pitcher Walter Johnson of the Washington Senators.
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The USS Missouri was nicknamed Big Mo and was the official site for the Japanese surrender at the end of WWII.
Clint Hurdle was born July 30, 1957, in Big Rapids, MI, USA.
In sports a first year player is a rookie. There are other terms used informally including greenhorn, especially when one comes up from the minor league (you made it to the "Big Show", "Big Dance", etc)
International Business Machines Corporation, abbreviated IBM and nicknamed "Big Blue" (for its official corporate color),
"We had a quick skirmish to train for the big battle."