Since 1915, only two "major" leagues have been in existence; and literally hundreds (if not thousands) of players have been on teams in both leagues.
During the seasons of 1914 and 1915, the Federal League operated; and Baseball history officially recognizes this as a "major" league. Scores of players -- including six future Hall of Famers -- played in this league as well as either the AL and the NL; so most likely dozens have played in three major leagues.
Likewise, a few entire TEAMS jumped from the Player's Association (1890) to the American Association, and then to the National League. Thus, some players went through three leagues in just over three years!
I doubt anyone has played in four leagues that are presently and unambiguously considered "major."
Ken Griffey Jr. Through games played on June 15, 2009 Griffey Jr. is the active player with the most base hits with 2714. Omar Viquel is second with 2676.
Joe Youngblood
Cal Ripkin
Hank Aaron was the last Negro League player to have a regular position in the Major League. Minnie Minoso was the last to actually play in a MLB game. (Two games for the White Sox in 1980.)
Rich Loiselle debuted on September 7, 1996, playing for the Pittsburgh Pirates at Three Rivers Stadium; he played his final game on October 6, 2001, playing for the Pittsburgh Pirates at PNC Park.
Omar Vizquel
Manny Ramirez is the top active non-Yankees player with the most postseason appearances with 111 games played.
None, there has never been a female player in Major League baseball.
Ken Griffey Jr. Through games played on June 15, 2009 Griffey Jr. is the active player with the most base hits with 2714. Omar Viquel is second with 2676.
Matsui
Michael Jordan almost did he played Mlb, Nba, and golf!
Deion Sanders
baseball player She played "All the way May"
derek jeeter
Yogi Berra.
He was a Major League Baseball player.
Joe Youngblood