Ryan Howard in 325 games.
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100
John Kruk hit 100 career home runs in 10 Major League seasons.
Ripper Collins of the St. Louis Cardinals with 35 in the 1934 season.
Depends what season
That was 46 home runs and 95 RBIs by Alfonso Soriano in 2006 for the Washington Nationals. Second highest was 45 home runs and 96 RBIs by Harmon Killebrew for the 1963 Minnesota Twins.