Most teams will use a five man rotation and based on this a starting pitcher will pitch every sixth day.
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In Major League Baseball there is no rule regarding pitcher's rest between games.
MLB teams have a five man starting rotation. That means the starting pitcher will pitch a game and not pitch for the next four games.
The heaviest pitcher in MLB History is definitely Nolan Ryan.
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He was a MLB pitcher from 1981-1989, pitched for 5 mlb teams.
Mariano Rivera