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31 VT players in the NFL according to ESPN.com
There are 32 players in the 2011 season.
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The ESPN NFL site says there are 22. It lists all the NFL players by college. It shows their position and pro team.
If you're physically able to, they will ask you to. If you turn them down, most NFL teams will take that as a sign of disrespect to the NFL. Many players do not attend the NFL combine. Players are invited to participate, but many players choose not to attend. It is helpful, but not necessary to improve you draft status. It is not considered disrespectful to the NFL to not attend the combine.